反应详情

To a solution of 2-(N-(tert.-butyloxycarbonyl)-amino)-2-methyl-1-(N-benzyloxycarbonyl-L-valyloxy)-propane (10 g, 23 mmole) in dichloromethane (150 ml) was added trifluoroacetic acid (30 ml) and the mixture was stirred for 1 hour at room temperature. The solution was evaporated under reduced pressure and 10% sodium carbonate solution was added. The product was extracted four times with dichloromethane, dried with sodium sulfate and evaporated under reduced pressure. The product was isolated by silica gel column chromatography with dichloromethane/methanol. Yield: 3.0 g=40% (crude)

1. customThe solution was evaporated under reduced pressure and 10% sodium carbonate solution
2. additionwas added
3. extractionThe product was extracted four times with dichloromethane
4. dry with materialdried with sodium sulfate
5. customevaporated under reduced pressure
6. customThe product was isolated by silica gel column chromatography with dichloromethane/methanol