反应详情

To a solution of the sulfoxide of Example 21 (0.92 g, 2.04 mmol) in dichloromethane (14 mL) and methanol (2 drops) was added trifluoroacetic acid (3.5 mL). This mixture was stirred for 4 h, and TLC indicated the absence of starting material. The volatile components were removed in vacuo and the residue was taken up into dichloromethane (50 mL) and washed with dilute aqueous sodium bicarbonate (2×). The organic phase was dried (Na2SO4), filtered and completely evaporated to leave 0.71 g of pure title compound.

1. customThe volatile components were removed in vacuo
2. washwashed with dilute aqueous sodium bicarbonate (2×)
3. dry with materialThe organic phase was dried (Na2SO4)
4. filtrationfiltered
5. customcompletely evaporated