Potassium Hydroxide → HCID 18419672, compound

HRID 990099Notes

Reaction equation

HRID 990099 reaction equation
[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH2:15][CH:14]([N:17]2[C:21]([CH3:22])=[C:20](S)[N:19]=[N:18]2)[CH2:13][CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[K+]>[N+]([O-])(O)=O>[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH2:15][CH:14]([N:17]2[C:21]([CH3:22])=[CH:20][N:19]=[N:18]2)[CH2:13][CH2:12]1)=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 18419702HCID 18419702, compound

Product 1

HCID 18419672HCID 18419672, compound

Reagents, catalysts & solvents 1

HCID 944Nitric AcidSolvent

Procedure

The compound of step (ii) (225 g) was dissolved by adding portions of 15-20 g to concentrated nitric acid (10M, 500 ml) on an ice bath with stirring. The mixture was stirred for 1 hr and poured onto an ice-cold solution of KOH (600 g) with continuous addition of ice. Then the reaction mixture was divided into 4 portions and each portion of 500 ml was extracted with 300 ml of chloroform. The combined organic layers were dried with anhydrous sodium sulfate and then evaporated in vacuo to give the title compound.

Workup

  1. stirringThe mixture was stirred for 1 hr
  2. extractioneach portion of 500 ml was extracted with 300 ml of chloroform
  3. dry with materialThe combined organic layers were dried with anhydrous sodium sulfate
  4. customevaporated in vacuo

Sources & evidence

ORD record
ord-d6a8c03fe5fc4335ad7e58959b8aff88
Source dataset
uspto-grants-2002_10
Patent number
US06458830B1

Reaction notes

Loading…