(+-)-3-Quinuclidinol → 1-(4,6-Diethoxy-1,3,5-triazin-2-yl)-3-hydroxyquinuclidinium chloride

HRID 990210Notes

Reaction equation

HRID 990210 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([O:8][CH2:9][CH3:10])[N:5]=[C:4]([O:11][CH2:12][CH3:13])[N:3]=1.[N:14]12[CH2:21][CH2:20][CH:17]([CH2:18][CH2:19]1)[CH:16]([OH:22])[CH2:15]2>>[Cl-:1].[CH2:12]([O:11][C:4]1[N:5]=[C:6]([O:8][CH2:9][CH3:10])[N:7]=[C:2]([N+:14]23[CH2:21][CH2:20][CH:17]([CH2:18][CH2:19]2)[CH:16]([OH:22])[CH2:15]3)[N:3]=1)[CH3:13]

Participants

3

Reactant 2

HCID 15381(+-)-3-QuinuclidinolHCID 356492-Chloro-4,6-diethoxy-1,3,5-triazine

Product 1

HCID 99055791-(4,6-Diethoxy-1,3,5-triazin-2-yl)-3-hydroxyquinuclidinium chloride

Procedure

The operation was carried out in the same manner as in Preparation Example 1 but using 4.07 g (0.02 mols) of a 2-chloro-4,6-diethoxy-1,3,5-triazine and 2.54 g (0.02 mols) of a 3-quinuclidinol to obtain 6.51 g (yield, 98.4%) of white crystals of a 1-(4,6-diethoxy-1,3,5-triazin-2-yl)-3-hydroxyquinuclidinium chloride represented by the following general formula (XII)

Workup

  1. customThe operation was carried out in the same manner as in Preparation Example 1
  2. customto obtain

Sources & evidence

ORD record
ord-df02c8ed69274451bdf10ff233cf0972
Source dataset
uspto-grants-2002_10
Patent number
US06458948B1

Reaction notes

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