Glycine, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl- → HCID 18418681, compound

HRID 990396Notes

Reaction equation

HRID 990396 reaction equation
C(OC(N(C)CC(O)=O)=O)(C)(C)C.C(O[C:19](=O)[N:20]([CH2:22][C:23](=[O:43])[NH:24][CH2:25][CH2:26][CH2:27][CH:28]([C:36]1[CH:41]=[CH:40][C:39]([F:42])=[CH:38][CH:37]=1)[C:29]1[CH:34]=[CH:33][C:32]([F:35])=[CH:31][CH:30]=1)C)(C)(C)C.C(OC(=O)NC)(C)(C)C>>[F:35][C:32]1[CH:31]=[CH:30][C:29]([CH:28]([C:36]2[CH:37]=[CH:38][C:39]([F:42])=[CH:40][CH:41]=2)[CH2:27][CH2:26][CH2:25][NH:24][C:23](=[O:43])[CH2:22][NH:20][CH3:19])=[CH:34][CH:33]=1

Participants

4

Reactant 3

HCID 83692Glycine, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-HCID 527635tert-Butyl methylcarbamateHCID 53712001HCID 53712001, compound

Product 1

HCID 18418681HCID 18418681, compound

Procedure

N-[4,4-Bis-(4-fluoro-phenyl)-butyl]-2-methylamino-acetamide was prepared in accordance with the methods of Example 12, except that N-tert-butoxycarbonyl-N-methyl-glycine was used instead of N-tert-butoxycarbonyl-N-methyl-L-leucine in Step A, and {[4,4-bis-(4-fluoro-phenyl)-butylcarbamoyl]-methyl}-methyl-carbamic acid tert-butyl ester was used instead of (S)-1-[4,4-bis-(4-fluoro-phenyl)-butylcarbamoyl]-3-methyl-butyl}-methyl-carbamic acid tert-butyl ester in Step B. MS: 333.2 (M+1 for C19H22N2F2O1); an oil;

Sources & evidence

ORD record
ord-aece324ba7244f7785434f5066986386
Source dataset
uspto-grants-2002_10
Patent number
US06458781B1

Reaction notes

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