Diethylene Glycol Monoethyl Ether → Ketamine

HRID 990583Notes

Reaction equation

HRID 990583 reaction equation
[CH3:1][NH:2][C:3]1([C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:15]=2[Cl:16])[C:8](=[O:9])[CH2:7][CH2:6][CH2:5][CH2:4]1.Cl.CCOCCOCCO>>[CH3:1][NH:2][C:3]1([C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:15]=2[Cl:16])[C:8](=[O:9])[CH2:7][CH2:6][CH2:5][CH2:4]1

Participants

3

Reactant 2

HCID 8146Diethylene Glycol Monoethyl EtherHCID 15851Ketamine Hydrochloride2×

Product 1

HCID 3821Ketamine

Procedure

0.3750 gm ketamine hydrochloride USP, is wetted with 1.5 ml of ethoxy diglycol reagent, and stirred into 75 gm of the base cream prepared as per example 3 and triple milled. A cream-type preparation results which contains ketamine hydrochloride @ 5 mg/ml.

Workup

  1. customA cream-type preparation
  2. customresults which

Sources & evidence

ORD record
ord-c03b220cadbf44c5bea1f1d688d2af4a
Source dataset
uspto-grants-2002_10
Patent number
US06461600B1

Reaction notes

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