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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 990584Generated: October 25, 2026

Diethylene Glycol Monoethyl Ether → Amitriptyline ketamine

https://huagongshe.com/reaction/990584

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDiethylene Glycol Monoethyl EtherHCID 8146—
ReactantAmitriptyline HydrochlorideHCID 11065—
ReactantKetamine HydrochlorideHCID 15851—
ProductAmitriptyline ketamineHCID 9892707—

Reaction Steps

0.3750 gm ketamine hydrochloride USP and 0.750 gm amitriptyline hydrochloride USP are combined and wetted with 2.0 ml of ethoxy diglycol reagent, and stirred into 75 gm of the base cream prepared as per example 3 and triple milled. The cream-type mixture contains ketamine hydrochloride at 5 mg/ml and amitriptyline hydrochloride at 10 mg/ml.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06461600B1
Source datasetuspto-grants-2002_10
ORD IDord-e770c9deff2d4242b4c06fba70b039da
Source noteuspto-grants-2002_10