HRID990584

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8146

2-(2-Ethoxyethoxy)ethanol

C6H14O3

HCID11065

Amitriptyline hydrochloride

C20H24ClN

2 次

HCID15851

Ketamine hydrochloride

C13H17Cl2NO

2 次

PRODUCTS

生成物

结构：CN(C)CCC=C1c2ccccc2CCc2ccccc21.CNC1(c2ccccc2Cl)CCCCC1=O

HCID9892707

未命名化合物

PROCEDURE

实验过程

0.3750 gm ketamine hydrochloride USP and 0.750 gm amitriptyline hydrochloride USP are combined and wetted with 2.0 ml of ethoxy diglycol reagent, and stirred into 75 gm of the base cream prepared as per example 3 and triple milled. The cream-type mixture contains ketamine hydrochloride at 5 mg/ml and amitriptyline hydrochloride at 10 mg/ml.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e770c9deff2d4242b4c06fba70b039da
来源数据集: uspto-grants-2002_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06461600B1
来源说明: uspto-grants-2002_10

反应 SMILES

[CH3:1][NH:2][C:3]1([C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:15]=2[Cl:16])[C:8](=[O:9])[CH2:7][CH2:6][CH2:5][CH2:4]1.Cl.[CH3:18][N:19]([CH2:21][CH2:22][CH:23]=[C:24]1[C:34]2[CH:35]=[CH:36][CH:37]=[CH:38][C:33]=2[CH2:32][CH2:31][C:30]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]1=2)[CH3:20].Cl.CCOCCOCCO>>[CH3:18][N:19]([CH2:21][CH2:22][CH:23]=[C:24]1[C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][C:30]=2[CH2:31][CH2:32][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][C:34]1=2)[CH3:20].[CH3:1][NH:2][C:3]1([C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:15]=2[Cl:16])[C:8](=[O:9])[CH2:7][CH2:6][CH2:5][CH2:4]1