Diclofenac sodium → Diclofenac

HRID 990889Notes

Reaction equation

HRID 990889 reaction equation
C(O)(=O)CCCCCCCCCCC/C=C\CCCCCCCC.[CH:25]1[CH:30]=[C:29]([CH2:31][C:32]([O-:34])=[O:33])[C:28]([NH:35][C:36]2[C:41]([Cl:42])=[CH:40][CH:39]=[CH:38][C:37]=2[Cl:43])=[CH:27][CH:26]=1.[Na+]>C(O)C>[CH:25]1[CH:26]=[CH:27][C:28]([NH:35][C:36]2[C:41]([Cl:42])=[CH:40][CH:39]=[CH:38][C:37]=2[Cl:43])=[C:29]([CH2:31][C:32]([OH:34])=[O:33])[CH:30]=1

Participants

4

Reactant 2

HCID 5018304Diclofenac sodiumHCID 5281116Erucic Acid2×

Product 1

HCID 3033Diclofenac

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A rectal suppository comprising erucic acid, beeswax, and the medicine diclofenac was prepared as follows: About 8.08 kg of micronized sodium diclofenac was added to a homogenous melt containing about 122.34 kg of erucic acid and about 13.57 kg of beeswax at a temperature of about 75° C. The medicine and suppository base was mixed gently until homogenous and the ethanol evaporated then poured into a mold. Upon cooling the suppository was removed from the mold.

Workup

  1. customevaporated
  2. additionthen poured into a mold
  3. temperatureUpon cooling the suppository
  4. customwas removed from the mold

Sources & evidence

ORD record
ord-481f1ea819d34825855d9335b98da7be
Source dataset
uspto-grants-2002_10
Patent number
US06462083B1

Reaction notes

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