反应详情

温度

0 °C

A mixture of 4-(1-oxospiro[indan-2,2′-oxiran]-3′-yl)benzoic acid (750 mg), methanol (30 ml) and hydrazine hydrate (0.16 ml) was stirred at ambient temperature whilst glacial acetic acid (6 drops) were added. The mixture was boiled under reflux for 24 hours and then allowed to stand at ambient temperature for 24 hours, then cooled to 0° C. and filtered to give methyl 4-(1,4-dihydroindeno [1,2-c]pyrazol-3-yl)benzoate, m.p. 224-226° C.

1. additionwere added
2. temperatureunder reflux for 24 hours
3. filtrationfiltered