Sodium Hydroxide → HCID 18415810, compound

HRID 990994Notes

Reaction equation

HRID 990994 reaction equation
[NH:1]1[C:5]2[C:6]3[C:11]([CH2:12][C:4]=2[C:3]([C:13]2[CH:14]=[C:15]([CH:23]=[CH:24][CH:25]=2)[O:16][CH2:17][C:18]([O:20]CC)=[O:19])=[N:2]1)=[CH:10][CH:9]=[CH:8][CH:7]=3.[OH-].[Na+]>C(O)C>[NH:1]1[C:5]2[C:6]3[C:11]([CH2:12][C:4]=2[C:3]([C:13]2[CH:14]=[C:15]([CH:23]=[CH:24][CH:25]=2)[O:16][CH2:17][C:18]([OH:20])=[O:19])=[N:2]1)=[CH:10][CH:9]=[CH:8][CH:7]=3

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 18415841HCID 18415841, compound

Product 1

HCID 18415810HCID 18415810, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of ethyl 3-(1,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenoxyacetate (0.66 g), 1M sodium hydroxide solution (4 ml) and ethanol (20 ml) was heated on a steam bath for 30 minutes. The solvent was removed under reduced pressure and the residue was stirred for 1 hour with 1M hydrochloric acid (20 ml) at ambient temperature. The mixture was filtered to give 3-(1,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenoxyacetic acid, m.p. 246-248° C.

Workup

  1. temperaturewas heated on a steam bath for 30 minutes
  2. customThe solvent was removed under reduced pressure
  3. filtrationThe mixture was filtered

Sources & evidence

ORD record
ord-025932611c814feda5357bb7a57b99eb
Source dataset
uspto-grants-2002_10
Patent number
US06462036B1

Reaction notes

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