Hydrochloric Acid → HCID 18415975, compound

HRID 991014Notes

Reaction equation

HRID 991014 reaction equation
C([N:4]1[C:8]2[C:9]3[C:14]([CH2:15][C:7]=2[C:6]([C:16]2[CH:25]=[CH:24][C:19]([NH:20][C:21](=[O:23])[CH3:22])=[CH:18][CH:17]=2)=[N:5]1)=[CH:13][CH:12]=[CH:11][CH:10]=3)(=O)C.[OH-].[Na+].[ClH:28]>CO>[ClH:28].[ClH:28].[NH:4]1[C:8]2[C:9]3[C:14]([CH2:15][C:7]=2[C:6]([C:16]2[CH:25]=[CH:24][C:19]([NH:20][C:21](=[O:23])[CH3:22])=[CH:18][CH:17]=2)=[N:5]1)=[CH:13][CH:12]=[CH:11][CH:10]=3

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 18415860HCID 18415860, compound

Product 1

HCID 18415975HCID 18415975, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4′-(1-acetyl-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)acetanilide (1.0 g) was suspended in methanol (40 ml) and a 2N aqueous solution of sodium hydroxide (15 ml) added. The mixture was stirred at ambient temperature for about 20 minutes and then poured onto an aqueous solution of 2N hydrochloric acid (75 ml), a colourless solid precipitated which was collected by filtration and dried in vacuo at about 60° C. to give 4′-(1,4-dihydroindeno[1,2-c]pyrazol-3-yl)acetanilide dihydrochloride (0.96 g) m.p. 295-304° C.

Workup

  1. customa colourless solid precipitated which
  2. filtrationwas collected by filtration
  3. customdried in vacuo at about 60° C.

Sources & evidence

ORD record
ord-9a3116230bfa404e9625dbb646dec23c
Source dataset
uspto-grants-2002_10
Patent number
US06462036B1

Reaction notes

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