1-(2-(4-(Chloromethyl)phenoxy)ethyl)azepane → 2-[4-(2-Azepan-1-yl-ethoxy)benzyl]-2-(4-methoxy-benzenesulfonyl)pentanoic acid ethyl ester
Reaction equation
[CH2:1]([O:3][C:4](=[O:20])[CH:5]([S:9]([C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=1)(=[O:11])=[O:10])[CH2:6][CH2:7][CH3:8])[CH3:2].Cl[CH2:22][C:23]1[CH:38]=[CH:37][C:26]([O:27][CH2:28][CH2:29][N:30]2[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]2)=[CH:25][CH:24]=1>>[CH2:1]([O:3][C:4](=[O:20])[C:5]([CH2:22][C:23]1[CH:24]=[CH:25][C:26]([O:27][CH2:28][CH2:29][N:30]2[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]2)=[CH:37][CH:38]=1)([S:9]([C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=1)(=[O:10])=[O:11])[CH2:6][CH2:7][CH3:8])[CH3:2]Participants
3
Procedure
2-[4-(2-Azepan-1-yl-ethoxy)benzyl]-2-(4-methoxy-benzenesulfonyl)pentanoic acid ethyl ester was prepared according to the general method as outlined in example 12. Starting from 2-(4-methoxy-benzenesulfonyl)pentanoic acid ethyl ester (3.5 g, 11.7 mmol) and 1-[2-(4-chloromethyl-phenoxy)ethyl]-azepane (3.9 g, 12.8 nmmol). Yield 2.58 g (42%); brown oil; MS: 532.4 (M+H)+.
Sources & evidence
- ORD record
- ord-031ca0bedaac4f15884445ea2df6001b
- Source dataset
- uspto-grants-2002_10
- Patent number
- US06462073B2
Reaction notes
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