HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-(4-(Chloromethyl)phenoxy)ethyl)azepane → 2-[4-(2-Azepan-1-yl-ethoxy)benzyl]-2-(4-methoxy-benzenesulfonyl)pentanoic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-(4-(Chloromethyl)phenoxy)ethyl)azepane | HCID 9882910 | — |
| Reactant | 2-(4-Methoxy-benzenesulfonyl)pentanoic acid ethyl ester | HCID 10979504 | — |
| Product | 2-[4-(2-Azepan-1-yl-ethoxy)benzyl]-2-(4-methoxy-benzenesulfonyl)pentanoic acid ethyl ester | HCID 54491696 | — |
Reaction Steps
2-[4-(2-Azepan-1-yl-ethoxy)benzyl]-2-(4-methoxy-benzenesulfonyl)pentanoic acid ethyl ester was prepared according to the general method as outlined in example 12. Starting from 2-(4-methoxy-benzenesulfonyl)pentanoic acid ethyl ester (3.5 g, 11.7 mmol) and 1-[2-(4-chloromethyl-phenoxy)ethyl]-azepane (3.9 g, 12.8 nmmol). Yield 2.58 g (42%); brown oil; MS: 532.4 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06462073B2 |
| Source dataset | uspto-grants-2002_10 |
| ORD ID | ord-031ca0bedaac4f15884445ea2df6001b |
| Source note | uspto-grants-2002_10 |