HCID 53756990, compound → HCID 18416721, compound

HRID 991040Notes

Reaction equation

HRID 991040 reaction equation
C([O:3][C:4](=[O:36])[C:5]([CH2:21][C:22]1[CH:27]=[CH:26][C:25]([O:28][CH2:29][CH2:30][N:31]([CH2:34][CH3:35])[CH2:32][CH3:33])=[CH:24][CH:23]=1)([S:10]([C:13]1[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=1)(=[O:12])=[O:11])[CH2:6][CH2:7][CH2:8][CH3:9])C>CO.[OH-].[Na+]>[CH2:34]([N:31]([CH2:32][CH3:33])[CH2:30][CH2:29][O:28][C:25]1[CH:24]=[CH:23][C:22]([CH2:21][C:5]([S:10]([C:13]2[CH:14]=[CH:15][C:16]([O:19][CH3:20])=[CH:17][CH:18]=2)(=[O:11])=[O:12])([CH2:6][CH2:7][CH2:8][CH3:9])[C:4]([OH:36])=[O:3])=[CH:27][CH:26]=1)[CH3:35]

Participants

4

Reactant 1

HCID 53756990HCID 53756990, compound

Product 1

HCID 18416721HCID 18416721, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

2-[4(2-Diethylamino-ethoxy)benzyl]-2-(4-methoxy-benzenesulfonyl)hexanoic acid was prepared starting from 2-[4-(2-diethylamino-ethoxy)benzyl]-2-(4-methoxy-benzenesulfonyl) hexanoic acid ethyl ester (8 g, 15.4 mmol) dissolved in methanol (200 ml) and 10 N NaOH (30 ml). The resulting mixture was worked up as outlined in example 1. Yield 3.88 a crude (51%); brown oil; MS: 492 (M+H)+.

Workup

  1. customYield 3.88 a crude (51%)

Sources & evidence

ORD record
ord-cb224add9799406ebdefc3650818e3cc
Source dataset
uspto-grants-2002_10
Patent number
US06462073B2

Reaction notes

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