Sodium Hydroxide → HCID 69825757, compound

HRID 991084Notes

Reaction equation

HRID 991084 reaction equation
C([O:3][C:4]([C:6]1([S:23]([C:26]2[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[CH:28][CH:27]=2)(=[O:25])=[O:24])[CH2:11][CH2:10][N:9]([CH2:12][C:13]2[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH:16]=[CH:15][CH:14]=2)[CH2:8][CH2:7]1)=[O:5])C.[OH-].[Na+]>CO>[CH3:33][O:32][C:29]1[CH:28]=[CH:27][C:26]([S:23]([C:6]2([C:4]([OH:5])=[O:3])[CH2:7][CH2:8][N:9]([CH2:12][C:13]3[C:22]4[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=4)[CH:16]=[CH:15][CH:14]=3)[CH2:10][CH2:11]2)(=[O:25])=[O:24])=[CH:31][CH:30]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 69825807HCID 69825807, compound

Product 1

HCID 69825757HCID 69825757, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4-(4-Methoxy-benzenesulfonyl)-1-napthalene-ylmethyl-piperidine-4-carboxylic acid was prepared starting from 4-(4-methoxy-benzenesulfonyl)napthalene-ylmethyl-piperidine-4- carboxylic acid ethyl ester (6.3 g, 13 mmol) dissolved in methanol (30 mL), 10N sodium hydroxide (30 mL) and tetrahydrofuiran (30 mL). The resulting reaction mixture was worked up as outlined in example 83. Yield 2.3 g (36%). yellow solid mp 226-228° C., MS: 440.0 (M+H)+.

Workup

  1. customThe resulting reaction mixture

Sources & evidence

ORD record
ord-0364a79e78fa4deda8a2dfbcfd292012
Source dataset
uspto-grants-2002_10
Patent number
US06462073B2

Reaction notes

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