Sodium Hydroxide → HCID 69825757, compound

Participants

Reaction Steps

4-(4-Methoxy-benzenesulfonyl)-1-napthalene-ylmethyl-piperidine-4-carboxylic acid was prepared starting from 4-(4-methoxy-benzenesulfonyl)napthalene-ylmethyl-piperidine-4- carboxylic acid ethyl ester (6.3 g, 13 mmol) dissolved in methanol (30 mL), 10N sodium hydroxide (30 mL) and tetrahydrofuiran (30 mL). The resulting reaction mixture was worked up as outlined in example 83. Yield 2.3 g (36%). yellow solid mp 226-228° C., MS: 440.0 (M+H)+.

Provenance & Evidence