Sodium Hydroxide → HCID 18416760, compound

HRID 991085Notes

Reaction equation

HRID 991085 reaction equation
C([O:3][C:4]([C:6]1([S:17]([C:20]2[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=2)(=[O:19])=[O:18])[CH2:11][CH2:10][N:9]([CH2:12][CH:13]=[C:14]([CH3:16])[CH3:15])[CH2:8][CH2:7]1)=[O:5])C.[OH-].[Na+]>C(O)C>[CH3:27][O:26][C:23]1[CH:22]=[CH:21][C:20]([S:17]([C:6]2([C:4]([OH:5])=[O:3])[CH2:11][CH2:10][N:9]([CH2:12][CH:13]=[C:14]([CH3:15])[CH3:16])[CH2:8][CH2:7]2)(=[O:19])=[O:18])=[CH:25][CH:24]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 54141522HCID 54141522, compound

Product 1

HCID 18416760HCID 18416760, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4-(4-Methoxy-benzenesulfonyl)-1-(3-methyl-but-2-enyl)-piperidine-4-carboxylic acid was prepared starting from 4-(4-methoxy-benzenesulfonyl)-1-(3-methyl-but-2-enyl)-piperidine-4- carboxylic acid ethyl ester (6.2 g, 16 mmol) dissolved in ethanol (15 mL), 10N sodium hydroxide (10 mL) and tetrahydrofiran (75 mL). The resulting reaction mixture was worked up as outlined in example 83. Yield 1.2 g (21%). brown solid mp 196-197° C., MS: 367.9 (M+H)+.

Workup

  1. customThe resulting reaction mixture

Sources & evidence

ORD record
ord-6dea94e616654986b2cd61f7d42935ca
Source dataset
uspto-grants-2002_10
Patent number
US06462073B2

Reaction notes

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