Hydrochloric Acid → 1-Aminoindane Hydrochloride

HRID 991260Notes

Reaction equation

HRID 991260 reaction equation
C([NH:8][CH:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH2:11][CH2:10]1)(OC(C)(C)C)=O.[ClH:18]>O1CCOCC1>[ClH:18].[NH2:8][CH:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH2:11][CH2:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 23203040HCID 23203040, compound

Product 1

HCID 27944411-Aminoindane Hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

6-(N-Me, N-Et Carbamyloxy) N-Boc aminoindan (7.8 g. 23.3 mmol) was dissolved in dioxane (80 ml), and a 20% solution of gas. HCl in dioxane (80 ml) was added. After 2 hr stirring at RT the solvent was evaporated in-vacuo and the residue was treated with dry ether (200 ml) and the mixture stirred at RT for 4 hrs and filtered, to give 6.15 g (0.7 mmol, 97%) of 6-(N-Me, N-Et carbamyloxy) aminoindan hydrochloride.

Workup

  1. customwas evaporated in-vacuo
  2. additionthe residue was treated with dry ether (200 ml)
  3. stirringthe mixture stirred at RT for 4 hrs
  4. filtrationfiltered

Sources & evidence

ORD record
ord-b93b5d5f3b5c4e7abe73a424346e6d13
Source dataset
uspto-grants-2002_10
Patent number
US06462222B1

Reaction notes

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