Methanol → HCID 12040393, compound

HRID 991267Notes

Reaction equation

HRID 991267 reaction equation
[CH:1]([OH:4])([CH3:3])[CH3:2].[CH3:5][OH:6]>>[CH:1]([O:4][C:5]([CH2:3][C:1]1[O:4][C:1]([CH3:3])([CH3:2])[O:4][C:5](=[O:6])[CH:2]=1)=[O:6])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 887MethanolHCID 3776Isopropanol

Product 1

HCID 12040393HCID 12040393, compound

Procedure

The reaction was carried out in the same manner as in Example 2 except that 10 mL of isopropyl alcohol was used as the alcohol in lieu of methanol. The reaction mixture was treated in the same manner as mentioned above and the organic layer obtained by phase separation was dried and concentrated to give 0.999 g of nearly pure 6-isopropoxycarbonylmethyl-2,2-dimethyl-4H-1,3-dioxin-4-one. The yield of 6-isopropoxycarbonylmethyl-2,2-dimethyl-4H-1,3-dioxin-4-one was 74 mol % based on the starting material 6-chloromethyl-2,2-dimethyl-4H-1,3-dioxin-4-one. The NMR spectrum data on this compound are shown below.

Workup

  1. additionThe reaction mixture was treated in the same manner
  2. customobtained by phase separation
  3. customwas dried
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-e399bc5a5aa040fc83ae7d32e4b56601
Source dataset
uspto-grants-2002_10
Patent number
US06462223B2

Reaction notes

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