L-Ornithine, 2-(difluoromethyl)-, monohydrochloride → L-Eflornithine

HRID 991272Notes

Reaction equation

HRID 991272 reaction equation
O.Cl.[F:3][CH:4]([F:14])[C@@:5]([C:11]([OH:13])=[O:12])([CH2:7][CH2:8][CH2:9][NH2:10])[NH2:6]>CO>[F:3][CH:4]([F:14])[C@@:5]([C:11]([OH:13])=[O:12])([CH2:7][CH2:8][CH2:9][NH2:10])[NH2:6]

Participants

3

Reactant 1

HCID 23393214L-Ornithine, 2-(difluoromethyl)-, monohydrochloride

Product 1

HCID 6992039L-Eflornithine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

From the evaporated mother liquor of the resolution from Example 1, according to the process described above, (+)-α-difluoromethylornithine monohydrochloride monohydrate was isolated with an optical rotation of [α]20D=+3.1° (c=7.0 in MeOH).

Sources & evidence

ORD record
ord-7a578809266b44528f6032f2f200a96c
Source dataset
uspto-grants-2002_10
Patent number
US06462229B1

Reaction notes

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