反应详情

温度

110 °C

8.55 g of 4-trifluoromethoxybenzaldehyde, 0.63 g of bis(triphenylphosphine) palladium dichloride and 6.12 g of sodium formate were placed in a flask fitted with a reflux condenser, 45 ml of DMF were added and the mixture was stirred and heated at 110° C. The course of the reaction was monitored by means of GC. After conversion was complete (GC monitoring), the reaction mixture was allowed to cool to 21° C. and the catalyst was separated off by filtration through silica gel. The filter was rinsed with methyl tert-butyl ether and the filtrate washed with 3×100 ml of water in order to remove the DMF. This gave 6.0 g (69% of theory) of 4-trifluoromethoxybenzyl alcohol.

1. customfitted with a reflux condenser
2. temperatureto cool to 21° C.
3. customthe catalyst was separated off by filtration through silica gel
4. washThe filter was rinsed with methyl tert-butyl ether
5. washthe filtrate washed with 3×100 ml of water in order
6. customto remove the DMF