Triethylamine → 1H-Imidazole-1-propanamine

HRID 991372Notes

Reaction equation

HRID 991372 reaction equation
[CH2:1]([N:3]([CH2:14][CH3:15])[C:4]1C=CC(F)=[C:6]([N+:11]([O-])=O)[CH:5]=1)C.C([N:18](CC)CC)C>>[N:3]1([CH2:4][CH2:5][CH2:6][NH2:11])[CH:14]=[CH:15][N:18]=[CH:1]1

Participants

3

Reactant 2

HCID 8471TriethylamineHCID 18413420HCID 18413420, compound

Product 1

HCID 787361H-Imidazole-1-propanamine

Procedure

A mixture of 8.8 g (0.041 mol) of diethyl(4-fluoro-3-nitrophenyl)amine obtained in the preceding stage, 17.0 g (0.136 mol) of 3-(imidazol-1-yl)propylamine (RN 5036-48-6) and 6.7 ml of triethylamine was heated at reflux with stirring for 2 hours.

Sources & evidence

ORD record
ord-8cb5bd3b4c264b8bbb2966b2904e194a
Source dataset
uspto-grants-2002_10
Patent number
US06464731B1

Reaction notes

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