反应详情

To a stirred mixture of 1-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane hydrochloride (578.8 mg, 2.16 mmol) and cycloheptanone (304 μl, 2.59 mmol) was added a solution of KCN (169 mg, 2.59 mmol) in water (1 ml) at room temperature. The reaction mixture was vigorously stirred at room temperature for 20 h. The precipitated white solid was collected by filtration, washed with water and hexane, and dried under vacuum at 50° C. for 1 h to afford 323 mg (42.4 %) of white powder.

1. filtrationThe precipitated white solid was collected by filtration
2. washwashed with water and hexane
3. customdried under vacuum at 50° C. for 1 h