Cyclohexanecarbonitrile, 1-(4-oxo-1-phenyl-1,3,8-triazaspiro(4,5)dec-8-yl)- → HCID 18414048, compound

HRID 991461Notes

Reaction equation

HRID 991461 reaction equation
[O:1]=[C:2]1[C:6]2([CH2:11][CH2:10][N:9]([C:12]3([C:18]#N)[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]3)[CH2:8][CH2:7]2)[N:5]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:4][NH:3]1.[CH2:26]([Mg]Br)[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>>[CH2:26]([C:12]1([N:9]2[CH2:8][CH2:7][C:6]3([N:5]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)[CH2:4][NH:3][C:2]3=[O:1])[CH2:11][CH2:10]2)[CH2:18][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17]1)[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1

Participants

3

Reactant 2

HCID 3063729Cyclohexanecarbonitrile, 1-(4-oxo-1-phenyl-1,3,8-triazaspiro(4,5)dec-8-yl)-HCID 178419663HCID 178419663, compound

Product 1

HCID 18414048HCID 18414048, compoundYield 54%

Procedure

This was prepared according to the procedure described in Example 1 using 1-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)cyclohexanecarbonitrile instead of 1-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)cycloheptanecarbonitrile and benzylmagnesium bromide instead of phenylmagnesium bromide. Yield was 54%.

Workup

  1. customThis was prepared

Sources & evidence

ORD record
ord-7250aba54e984e5f9aa4c30c273f9e75
Source dataset
uspto-grants-2002_10
Patent number
US06465478B1

Reaction notes

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