Dichloromethane → 1-[(2,6-Dichloropyridin-4-yl)carbonyl]-4-methylpiperazine, hydrochloride

Participants

Reaction Steps

To methylene chloride (15 mL) was added 2,6-dichloropyridine-4-carbonyl chloride (1.0 g, 4.8 mmol) and 1-methylpiperazine (0.48 g, 4.8 mmol). After stirring for 1 day, the reaction was poured into ether. The resulting solid was filtered to give 1-[(2,6-dichloropyridin-4-yl)-carbonyl]-4-methylpiperazine, hydrochloride.

Provenance & Evidence