Dichloromethane → 1-[(2,6-Dichloropyridin-4-yl)carbonyl]-4-methylpiperazine, hydrochloride

HRID 991472Notes

Reaction equation

HRID 991472 reaction equation
C(Cl)[Cl:2].[Cl:4][C:5]1[CH:10]=[C:9]([C:11](Cl)=[O:12])[CH:8]=[C:7]([Cl:14])[N:6]=1.[CH3:15][N:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1>CCOCC>[ClH:2].[Cl:4][C:5]1[CH:10]=[C:9]([C:11]([N:19]2[CH2:20][CH2:21][N:16]([CH3:15])[CH2:17][CH2:18]2)=[O:12])[CH:8]=[C:7]([Cl:14])[N:6]=1

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 531671-MethylpiperazineHCID 27816432,6-Dichloro-isonicotinoyl chloride

Product 1

HCID 1317203351-[(2,6-Dichloropyridin-4-yl)carbonyl]-4-methylpiperazine, hydrochloride

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To methylene chloride (15 mL) was added 2,6-dichloropyridine-4-carbonyl chloride (1.0 g, 4.8 mmol) and 1-methylpiperazine (0.48 g, 4.8 mmol). After stirring for 1 day, the reaction was poured into ether. The resulting solid was filtered to give 1-[(2,6-dichloropyridin-4-yl)-carbonyl]-4-methylpiperazine, hydrochloride.

Workup

  1. filtrationThe resulting solid was filtered

Sources & evidence

ORD record
ord-da0d11b4114342d795311d9a7b976e73
Source dataset
uspto-grants-2002_10
Patent number
US06465459B2

Reaction notes

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