Potassium Carbonate → HCID 86758568, compound

HRID 991500Notes

Reaction equation

HRID 991500 reaction equation
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8]Cl)=[CH:4][CH:3]=1.[CH3:10][C:11]1[CH:16]=[CH:15][C:14]([S:17]([N:20]=[C:21]2[NH:25][CH2:24][CH2:23][S:22]2)(=[O:19])=[O:18])=[CH:13][CH:12]=1.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][N:25]2[CH2:24][CH2:23][S:22][C:21]2=[N:20][S:17]([C:14]2[CH:15]=[CH:16][C:11]([CH3:10])=[CH:12][CH:13]=2)(=[O:19])=[O:18])=[CH:6][N:7]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 1554792-Chloro-5-(chloromethyl)pyridineHCID 178427427HCID 178427427, compound

Product 1

HCID 86758568HCID 86758568, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture of 1.62 g of 6-chloro-3-chloromethyl pyridine (CCMP), 2.56 g of 2-[(4-methylphenyl) sulfonylimino]thiazolidine, 3.0 g of potassium carbonate, and 50 ml acetonitrile was heated under reflux for 3 hours. After the reaction, the product in the reaction mixture was purified by known crystallization techniques to yield pale yellowish crystals of 3.51 g 3-(2-chloro-5-pyridylmethyl)-2-[(4-methylphenyl)sulfonylimino]thiazolidine. The thus formed crystals have a melting point in a range of from 162.1 to 162.8° C.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 3 hours
  3. customAfter the reaction
  4. customthe product in the reaction mixture was purified by known crystallization techniques

Sources & evidence

ORD record
ord-34d69a3f3edf4a7ea9068a1f4be9c071
Source dataset
uspto-grants-2002_10
Patent number
US06465492B1

Reaction notes

Loading…