N-(Propan-2-yl)-2H-1,3-benzodioxol-5-amine → 1-(1,3-Benzodioxol-5-yl)-1-isopropylurea

HRID 991508Notes

Reaction equation

HRID 991508 reaction equation
[CH:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]2[O:11][CH2:12][O:13][C:7]=2[CH:6]=1)([CH3:3])[CH3:2].[O:14]([C:16]#[N:17])[Na]>>[CH:1]([N:4]([C:5]1[CH:10]=[CH:9][C:8]2[O:11][CH2:12][O:13][C:7]=2[CH:6]=1)[C:16]([NH2:17])=[O:14])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 12789466N-(Propan-2-yl)-2H-1,3-benzodioxol-5-amineHCID 178418852HCID 178418852, compound

Product 1

HCID 1005551-(1,3-Benzodioxol-5-yl)-1-isopropylureaYield 83%

Procedure

The title compound was prepared from N-isopropyl-3,4-(methylenedioxy)aniline and NaOCN by the procedure described in example 5 in 83% yield. 1H NMR (CDCl3): 6.85-6.65 (m, 3H), 6.04 (s, 2H), 4.82 (m, 1H), 4.21 (br s, 2H), 1.06 (d, J=6.6, 6H).

Sources & evidence

ORD record
ord-49498f9acb064efabf48cf4af13f3053
Source dataset
uspto-grants-2002_10
Patent number
US06465472B1

Reaction notes

Loading…