Potassium Carbonate → HCID 23505716, compound

HRID 991535Notes

Reaction equation

HRID 991535 reaction equation
[CH2:1]1[O:20][C:19]2[C:3](=[CH:4][C:5]([NH:21]C(=O)C(F)(F)F)=[C:6]([CH:18]=2)[C:7]([C:9]2[CH:14]=[CH:13][C:12]3[O:15][CH2:16][O:17][C:11]=3[CH:10]=2)=[O:8])[O:2]1.C(=O)([O-])[O-].[K+].[K+]>CO>[NH2:21][C:5]1[CH:4]=[C:3]2[O:2][CH2:1][O:20][C:19]2=[CH:18][C:6]=1[C:7]([C:9]1[CH:14]=[CH:13][C:12]2[O:15][CH2:16][O:17][C:11]=2[CH:10]=1)=[O:8]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 23505704HCID 23505704, compound

Product 1

HCID 23505716HCID 23505716, compoundYield 74.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 4,5-methylenedioxy-2-trifluoroacetamido-(3′,4′-methylenedioxy)benzophenone (5 g, 13.12 mmol) in methanol at 50° C. was treated with a solution of potassium carbonate (3.63 g, in 30 mL water) and stirred for 5 h. The reaction mixture was cooled in an ice bath for 20 min. The resulting solid was filtered and then dissolved in ethyl acetate, dried over anhydrous MgSO4, and concentrated to give a crude yellow product (2.8 g).

Workup

  1. temperatureThe reaction mixture was cooled in an ice bath for 20 min
  2. filtrationThe resulting solid was filtered
  3. dissolutiondissolved in ethyl acetate
  4. dry with materialdried over anhydrous MgSO4
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-2f420cf06ec245de8e9aacb4b1ae5334
Source dataset
uspto-grants-2002_10
Patent number
US06465472B1

Reaction notes

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