反应详情

A mixture of 3,5-dimethyl-fluorobenzene (5 g, 0.04 mol), paraformaldehyde (15 g), hydrobromic acid (70 ml) (30% in acetic acid) and acetic acid (25 ml) was stirred at ambient temperature for 4.5 h. To the mixture were water and petroleum ether added and the organic layer was separated dried over anhydrous sodium sulfate and evaporated carefully under reduced pressure. The residue was purified by column chromatography on silica gel with petroleum ether as eluent to give the title product. (3.7 g, 43%)

1. additionadded
2. customthe organic layer was separated
3. dry with materialdried over anhydrous sodium sulfate
4. customevaporated carefully under reduced pressure
5. customThe residue was purified by column chromatography on silica gel with petroleum ether as eluent