1-Ethylpiperazine → HCID 22036259, compound

HRID 991616Notes

Reaction equation

HRID 991616 reaction equation
Cl[C:2]1[C:7]([O:8][CH2:9][CH2:10][O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[Cl:18])=[N:6][CH:5]=[CH:4][N:3]=1.[CH2:19]([N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1)[CH3:20]>>[CH2:19]([N:21]1[CH2:26][CH2:25][N:24]([C:2]2[C:7]([O:8][CH2:9][CH2:10][O:11][C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[Cl:18])=[N:6][CH:5]=[CH:4][N:3]=2)[CH2:23][CH2:22]1)[CH3:20]

Participants

3

Reactant 2

HCID 791961-EthylpiperazineHCID 11483009HCID 11483009, compound

Product 1

HCID 22036259HCID 22036259, compound

Procedure

The title compound was prepared in an analogous manner to Example 4, Step 2, starting from 2-chloro-3-[2-(2-chlorophenoxy)ethoxy]pyrazine* (150 mg, 0.53 mmol) and N-ethylpiperazine (221 mg, 1.93 mmol) with the exception that a final extraction step between EtOAc and 5% aqueous NaOH was carried out. This gave 100 mg (52%) of the title product. Anal. (C18H24C14O2) C, H, N.

Workup

  1. extractionextraction step between EtOAc and 5% aqueous NaOH

Sources & evidence

ORD record
ord-ae231ed990a44809bc38ebdb8f84244f
Source dataset
uspto-grants-2002_10
Patent number
US06465467B1

Reaction notes

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