HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Pyridin-3-yloxy)ethan-1-ol → PRX933 hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Pyridin-3-yloxy)ethan-1-ol | HCID 21908997 | — |
| Reactant | (R)-tert-butyl 4-(3-chloropyrazin-2-yl)-3-methylpiperazine-1-carboxylate | HCID 86591091 | — |
| Product | PRX933 hydrochloride | HCID 131723551 | — |
Reaction Steps
The title compound was prepared starting from 2-(3-pyridyloxy)ethanol (from Example 150, Step 1) and 3-chloro-2-[4-tert-butoxycarbonyl-(2R)-methyl-1-piperazinyl]pyrazine (from Example 172, Step 2). The pure free base was precipitated as its hydrochloride salt with HCl/ether to give the title compound as white crystals: yield 31%; mp 180-183° C.; HRMS m/z calcd for C16H21N5O2 (M)+ 315.1695, found 315.1689. Anal. (C16H21N5O2.1.33HCl) C, H, N.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06465467B1 |
| Source dataset | uspto-grants-2002_10 |
| ORD ID | ord-97b44900692144ac8dad4aeb04497f7b |
| Source note | uspto-grants-2002_10 |