HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 131723552, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-(Pyridin-3-yloxy)ethan-1-ol | HCID 21908997 | — |
| Reactant | HCID 87650681 | HCID 87650681 | — |
| Product | HCID 131723552 | HCID 131723552 | 58% |
Reaction Steps
The title compound was prepared starting from 2-(3-pyridyloxy)ethanol (from Example 150, Step 1) and 3-chloro-2-[4-tert-butoxycarbonyl-(2S)-methyl-1-piperazinyl]pyrazine (prepared according to the procedure of Example 172, Step 2, with the exception that (2S)-methylpiperazine was substituted for (2R)-methylpiperazine). MS m/z 316 (M+H)+. Yield 58%; mp 170-172° C. Anal. (C16H21N5O2.1.45 HCl) C, H, N.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06465467B1 |
| Source dataset | uspto-grants-2002_10 |
| ORD ID | ord-76d9cd60ba2d4002949ce53d69b3b946 |
| Source note | uspto-grants-2002_10 |