Hydrochloric Acid → HCID 131723552, compound

HRID 991667Notes

Reaction equation

HRID 991667 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([O:7][CH2:8][CH2:9][OH:10])[CH:2]=1.[Cl:11][C:12]1[C:13]([N:18]2[CH2:23][CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20][C@@H:19]2[CH3:31])=[N:14][CH:15]=[CH:16][N:17]=1.Cl>>[ClH:11].[CH3:31][C@H:19]1[CH2:20][NH:21][CH2:22][CH2:23][N:18]1[C:13]1[C:12]([O:10][CH2:9][CH2:8][O:7][C:3]2[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=2)=[N:17][CH:16]=[CH:15][N:14]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 219089972-(Pyridin-3-yloxy)ethan-1-olHCID 87650681HCID 87650681, compound

Product 1

HCID 131723552HCID 131723552, compoundYield 58%

Procedure

The title compound was prepared starting from 2-(3-pyridyloxy)ethanol (from Example 150, Step 1) and 3-chloro-2-[4-tert-butoxycarbonyl-(2S)-methyl-1-piperazinyl]pyrazine (prepared according to the procedure of Example 172, Step 2, with the exception that (2S)-methylpiperazine was substituted for (2R)-methylpiperazine). MS m/z 316 (M+H)+. Yield 58%; mp 170-172° C. Anal. (C16H21N5O2.1.45 HCl) C, H, N.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-76d9cd60ba2d4002949ce53d69b3b946
Source dataset
uspto-grants-2002_10
Patent number
US06465467B1

Reaction notes

Loading…