Phenoxyethanol → HCID 131723553, compound

HRID 991668Notes

Reaction equation

HRID 991668 reaction equation
[O:1]([CH2:8][CH2:9][OH:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:11][C:12]1[C:13]([N:18]2[CH2:23][CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20][C@@H:19]2[CH3:31])=[N:14][CH:15]=[CH:16][N:17]=1>>[ClH:11].[CH3:31][C@H:19]1[CH2:20][NH:21][CH2:22][CH2:23][N:18]1[C:13]1[C:12]([O:10][CH2:9][CH2:8][O:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[N:17][CH:16]=[CH:15][N:14]=1

Participants

3

Reactant 2

HCID 31236PhenoxyethanolHCID 87650681HCID 87650681, compound

Product 1

HCID 131723553HCID 131723553, compoundYield 68%

Procedure

The title compound was prepared starting from 2-phenoxy-1-ethanol and 3-chloro-2-[4-tert-butoxycarbonyl-(2S)-methyl-1-piperazinyl]pyrazine (prepared according to the procedure of Example 172, Step 2, with the exception that (2S)-methylpiperazine was substituted for (2R)-methylpiperazine). MS m/z 315 (M+H)+. Yield 68%; mp 162-163° C. Anal. (C17H22N4O2.HCl) C, H, N.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-06be1a9416044541b5ec6425608e29c1
Source dataset
uspto-grants-2002_10
Patent number
US06465467B1

Reaction notes

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