HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 3,5-Bis(2-hydroxyphenyl)-1-benzyl-1H-[1,2,4]triazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Hydrazine, (phenylmethyl)-, hydrochloride (1:1) | HCID 14084 | — |
| Reactant | 2-(2-Hydroxyphenyl)-4H-1,3-benzoxazin-4-one | HCID 135685723 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3,5-Bis(2-hydroxyphenyl)-1-benzyl-1H-[1,2,4]triazole | HCID 135817484 | — |
Reaction Steps
5.0 g of 2-(2-hydroxyphenyl)benz[e][1,3]oxazin-4-one are boiled under reflux for 4 h with 3.4 g of benzylhydrazine hydrochloride and 5.9 ml of triethylamine in 50 ml of ethanol. The mixture is cooled, poured onto water and extracted with ethyl acetate. The combined organic phases are dried over sodium sulfate and concentrated on a rotary evaporator. The residue is crystallized from isopropanol. After drying, 3,5-bis(2-hydroxyphenyl)-1-benzyl-1H-[1,2,4]triazole remains as colorless crystals of m.p. 166-168° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06465504B1 |
| Source dataset | uspto-grants-2002_10 |
| ORD ID | ord-cdde8be6120040a7b8644db2fc1d792e |
| Source note | uspto-grants-2002_10 |