反应详情

5.0 g of 2-(2-hydroxyphenyl)benz[e][1,3]oxazin-4-one are boiled under reflux for 4 h with 3.4 g of benzylhydrazine hydrochloride and 5.9 ml of triethylamine in 50 ml of ethanol. The mixture is cooled, poured onto water and extracted with ethyl acetate. The combined organic phases are dried over sodium sulfate and concentrated on a rotary evaporator. The residue is crystallized from isopropanol. After drying, 3,5-bis(2-hydroxyphenyl)-1-benzyl-1H-[1,2,4]triazole remains as colorless crystals of m.p. 166-168° C.

1. temperatureThe mixture is cooled
2. additionpoured onto water
3. extractionextracted with ethyl acetate
4. dry with materialThe combined organic phases are dried over sodium sulfate
5. concentrationconcentrated on a rotary evaporator
6. customThe residue is crystallized from isopropanol
7. customAfter drying