Hydrochloric Acid → [3,5-Bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]acetic acid

HRID 991723Notes

Reaction equation

HRID 991723 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:12]=[C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[OH:19])[N:10]([CH2:20][C:21]([O:23]CC)=[O:22])[N:9]=1.[OH-].[Na+].Cl>CO>[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:12]=[C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[OH:19])[N:10]([CH2:20][C:21]([OH:23])=[O:22])[N:9]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 135914986Ethyl [3,5bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]acetate

Product 1

HCID 135817464[3,5-Bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]acetic acid

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.6 g of ethyl [3,5-bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]acetate (Example 2) is dissolved in 20 ml of methanol with 0.4 g of sodium hydroxide and the mixture is stirred at room temperature for 2 h. It is acidified with 0.1 N hydrochloric acid and the precipitated crystals are filtered off. After washing with water and drying, [3,5-bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]acetic acid remains as colorless crystals of m.p. 231-233° C.

Workup

  1. filtrationthe precipitated crystals are filtered off
  2. washAfter washing with water
  3. customdrying

Sources & evidence

ORD record
ord-eb530827bcab4502a675e96bf7f11626
Source dataset
uspto-grants-2002_10
Patent number
US06465504B1

Reaction notes

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