3-Amino-1-propanol → HCID 43390104, compound

HRID 991748Notes

Reaction equation

HRID 991748 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[C:2]1[C:10]([OH:12])=O.[NH2:13][CH2:14][CH2:15][CH2:16][OH:17]>>[OH:17][CH2:16][CH2:15][CH2:14][NH:13][C:10]([C:2]1[O:1][C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=1)=[O:12]

Participants

3

Reactant 2

HCID 90863-Amino-1-propanolHCID 10331Benzofuran-2-carboxylic acid

Product 1

HCID 43390104HCID 43390104, compoundYield 20.6%

Procedure

2-Benzofurancarboxylic acid (5.0 g, 30.8 mmol) and 3-amino-1-propanol (2.83 ml, 37 mmol) were coupled according to the procedure of example 22 to provide 1.39 g (17.2% yield) of the desired product as a yellow solid. Electrospray Mass Spec: m/z 219.8 (M+H)+.

Sources & evidence

ORD record
ord-99a26bb109c3447ab91480dea6059c8b
Source dataset
uspto-grants-2002_10
Patent number
US06465508B1

Reaction notes

Loading…