Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl 2-Carbobenzyloxyamino-3-(4-tert-butoxycarbonylpiperazin-1-yl)propionate → Methyl 2-Amino-3-(4-tert-butoxycarbonylpiperazin-1-yl)propionate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl 2-Carbobenzyloxyamino-3-(4-tert-butoxycarbonylpiperazin-1-yl)propionate | HCID 21940471 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Palladium | HCID 23938 | — |
| 생성물 | Methyl 2-Amino-3-(4-tert-butoxycarbonylpiperazin-1-yl)propionate | HCID 21940545 | — |
반응 단계
The title material from Step A was dissolved in methanol with catalytic amount of 10% Pd on C. The reaction mixture was hydrogenated for 2 hours at room temperature in methanol under 25 psi of hydrogen. After filtration of the crude reaction mixture through a pad of Celite, the solvent was evaporated under reduced pressure to afford the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06465513B1 |
| 출처 데이터셋 | uspto-grants-2002_10 |
| ORD ID | ord-c18e748494f643b8b41d754325ee1c26 |
| 출처 메모 | uspto-grants-2002_10 |