HCID 12967140, compound → tert-Butyl 6-oxo-3,6-dihydropyridine-1(2H)-carboxylate

HRID 991788Notes

Reaction equation

HRID 991788 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH2:11][CH:10](S(C2C=CC=CC=2)(=O)=O)[C:9]1=[O:23])=[O:7])([CH3:4])([CH3:3])[CH3:2]>C1(C)C=CC=CC=1>[C:1]([O:5][C:6]([N:8]1[C:9](=[O:23])[CH:10]=[CH:11][CH2:12][CH2:13]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 1

HCID 12967140HCID 12967140, compound

Product 1

HCID 66598173tert-Butyl 6-oxo-3,6-dihydropyridine-1(2H)-carboxylate

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

3-Benzenesulfonyl-2-oxo-piperidine-1-carboxylic acid tert-butyl ester from above in toluene (50 mL) was heated at 80° C. for one hour. The reaction mixture was concentrated and the resulting oil was purified by column chromatography (20-30% EtOAc in Hexane) to give 2 g of 6-oxo-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester as an oil.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customthe resulting oil was purified by column chromatography (20-30% EtOAc in Hexane)

Sources & evidence

ORD record
ord-3c9b1931c1a540a58d33fe714238485c
Source dataset
uspto-grants-2002_10
Patent number
US06465507B2

Reaction notes

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