Piperidine → HCID 69706997, compound

HRID 991837Notes

Reaction equation

[N:1]1([C:6]([C:8]2[CH:9]=[C:10]3[C:14](=[CH:15][CH:16]=2)[NH:13][C:12](=[O:17])[CH2:11]3)=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2]1.[O:18]=[C:19]1[C:24]2=[CH:25][NH:26][C:27]([CH:28]=O)=[C:23]2[CH2:22][CH2:21][NH:20]1.N1CCCCC1>C(O)C>[O:17]=[C:12]1[C:11](=[CH:28][C:27]2[NH:26][CH:25]=[C:24]3[C:23]=2[CH2:22][CH2:21][NH:20][C:19]3=[O:18])[C:10]2[C:14](=[CH:15][CH:16]=[C:8]([C:6]([N:1]3[CH2:5][CH2:4][CH2:3][CH2:2]3)=[O:7])[CH:9]=2)[NH:13]1

Participants

Conditions

Temperature: 80 °C

Procedure

A mixture of 5-(pyrrolidine-1-carbonyl)-1,3-dihydro-indol-2-one (46 mg, 0.2 mmol), 4-oxo-4,5,6,7-tetrahydro-2H-pyrrolo[3,4-c]pyridine-1-carbaldehyde (1 equivalent) and 0.1 mL of piperidine in ethanol (1 mL) was heated in a sealed tube at 80° C. for 3 hours. The precipitate was collected by vacuum filtration, washed with ethanol and dried to give the title compound as a yellow solid.

Workup

filtrationThe precipitate was collected by vacuum filtration
washwashed with ethanol
customdried

Sources & evidence

ORD record: ord-8050f62d507e429686ab0e9771d57401
Source dataset: uspto-grants-2002_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06465507B2

Reaction notes

Loading…