Chlorosulfonic acid → HCID 85790784, compound

HRID 991847Notes

Reaction equation

HRID 991847 reaction equation
[OH:1][CH2:2][CH2:3][C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[CH2:6][C:7](=[O:13])[NH:8]2.Cl[S:15](O)(=[O:17])=[O:16]>>[O:16]=[S:15]1(=[O:17])[O:1][CH2:2][CH2:3][C:4]2[C:12]1=[CH:11][CH:10]=[C:9]1[NH:8][C:7](=[O:13])[CH2:6][C:5]1=2

Participants

3

Reactant 2

HCID 24638Chlorosulfonic acidHCID 109430044-(2-Hydroxyethyl)indolin-2-one

Product 1

HCID 85790784HCID 85790784, compoundYield 28%

Procedure

4-Hydroxyethyl-2-oxindole (5 g, 28.2 mmol) was dissolved in 20 mL of chlorosulfonic acid with stirring at room temperature. After 30 min, the reaction mixture was slowly added to ice water (300 mL) with stirring. The solid was filtered and dried to afford 1.9 g (28%) of 6,6-dioxo-3,6,8,9-tetrahydro-1H-7-oxa-6λ6-thia-3-aza-cyclopenta[α]naphthalen-2-one as a white powder.

Workup

  1. stirringwith stirring
  2. filtrationThe solid was filtered
  3. customdried

Sources & evidence

ORD record
ord-f33f4203d3734107b99f5dc2e18bbed4
Source dataset
uspto-grants-2002_10
Patent number
US06465507B2

Reaction notes

Loading…