Chlorosulfonic acid → HCID 85790784, compound

Participants

Reaction Steps

4-Hydroxyethyl-2-oxindole (5 g, 28.2 mmol) was dissolved in 20 mL of chlorosulfonic acid with stirring at room temperature. After 30 min, the reaction mixture was slowly added to ice water (300 mL) with stirring. The solid was filtered and dried to afford 1.9 g (28%) of 6,6-dioxo-3,6,8,9-tetrahydro-1H-7-oxa-6λ6-thia-3-aza-cyclopenta[α]naphthalen-2-one as a white powder.

Provenance & Evidence