HCID 15942001, compound → HCID 18415120, compound

HRID 991981Notes

Reaction equation

HRID 991981 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:14]=[C:15]([Br:28])[C:16]=1[O:17][C:18]1[CH:23]=[CH:22][C:21]([OH:24])=[C:20]([CH:25]([CH3:27])[CH3:26])[CH:19]=1)[CH2:5][P:6](=[O:13])([O:10]CC)[O:7]CC>Cl>[Br:28][C:15]1[CH:14]=[C:4]([CH:3]=[C:2]([Br:1])[C:16]=1[O:17][C:18]1[CH:23]=[CH:22][C:21]([OH:24])=[C:20]([CH:25]([CH3:26])[CH3:27])[CH:19]=1)[CH2:5][P:6](=[O:7])([OH:10])[OH:13]

Participants

3

Reactant 1

HCID 15942001HCID 15942001, compound

Product 1

HCID 18415120HCID 18415120, compoundYield 53.6%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A mixture of 3,5-dibromo-4-(4-hydroxy-3-isopropylphenoxy) benzyl phosphonic acid, diethyl ester (21 mg, 0.0392 mmol) in 2 ml of 6 M HCl was refluxed for 24 hours. The reaction mixture was concentrated and the residue was recrystallized with EtOH/water to give 10 mg (0.021 mmol, 53%) of 3,5-dibromo-4-(4-hydroxy-3-isopropylphenoxy)-benzylphosphonic acid as white crystalls.

Workup

  1. temperaturewas refluxed for 24 hours
  2. concentrationThe reaction mixture was concentrated
  3. customthe residue was recrystallized with EtOH/water

Sources & evidence

ORD record
ord-8fdbc199de314e1cbd8ecc318c20b7db
Source dataset
uspto-grants-2002_10
Patent number
US06465687B1

Reaction notes

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