1H-Pyrrolo(2,3-b)pyridine → 3-(1,4-Dioxa-spiro[4,5]dec-7-en-8-yl)-1H-azaindole

HRID 992010Notes

Reaction equation

HRID 992010 reaction equation
[O:1]1[C:5]2([CH2:10][CH2:9][C:8]([C:11]3[C:19]4[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=4)[NH:13]C=3)=[CH:7][CH2:6]2)[O:4][CH2:3][CH2:2]1.[NH:20]1C2C(=CC=CN=2)C=C1>>[O:1]1[C:5]2([CH2:10][CH2:9][C:8]([C:11]3[C:19]4[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=4)[NH:13][N:20]=3)=[CH:7][CH2:6]2)[O:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 92221H-Pyrrolo(2,3-b)pyridineHCID 27638573-(1,4-Dioxaspiro[4.5]dec-7-en-8-yl)-1H-indole

Product 1

HCID 184141013-(1,4-Dioxa-spiro[4,5]dec-7-en-8-yl)-1H-azaindoleYield 68%

Procedure

This compound was prepared in the manner described above for intermediate 1a by replacing indole with 7-azaindole (3.65 g, 31 mmol) in 68% yield (5.42 g) as a white solid: mp 162-165° C.; MS EI m/e 256 (M+).

Workup

  1. customThis compound was prepared in the manner

Sources & evidence

ORD record
ord-8e38bfc1c69f4b77b0ae96550d23bff5
Source dataset
uspto-grants-2002_10
Patent number
US06465482B2

Reaction notes

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