3-(1,4-Dioxa-spiro[4,5]dec-7-en-8-yl)-5-fluoro-1H-indole → 4-(5-Fluoro-1H-3-indolyl)-cyclohex-3-enone

HRID 992045노트

반응식

HRID 992045 반응식
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][C:14](=[O:17])[CH2:13][CH2:12]1.C1OC2(CCC(C3C4C(=CC=C(F)C=4)NC=3)=CC2)OC1>>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[C:11]1[CH2:16][CH2:15][C:14](=[O:17])[CH2:13][CH:12]=1

참가 물질

3

반응물 2

HCID 105163803-(1,4-Dioxa-spiro[4,5]dec-7-en-8-yl)-5-fluoro-1H-indoleHCID 107046834-(5-Fluoro-1H-indol-3-YL)cyclohexanone

생성물 1

HCID 184140964-(5-Fluoro-1H-3-indolyl)-cyclohex-3-enone수율 88%

실험 절차

This compound was prepared in the manner described above for intermediate 3c by replacing 4-(5-fluoro-1H-3-indolyl)-cyclohexanone ethylene ketal with 4-(5-fluoro-1H-3-indolyl)-cyclohex-3-enone-ethylene ketal (1.37 g) to afford 1.01 g (88%) of the title compound.

후처리

  1. customThis compound was prepared in the manner

출처 및 근거

ORD 기록
ord-c4646cb54d5248fb8a957bfe2cebe7d4
출처 데이터셋
uspto-grants-2002_10
특허 번호
US06465482B2

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