HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 992161Generated: October 25, 2026
Acetyl chloride → 1,3-Bis(acetylamino)adamantane
https://huagongshe.com/reaction/992161
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Adamantane-1,3-diamine | HCID 213512 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1,3-Bis(acetylamino)adamantane | HCID 2817797 | 95% |
Reaction Steps
In an atmosphere of nitrogen, 22 mmole of acetyl chloride and 24 mmole of triethylamine were dissolved in 2 ml of tetrahydrofurane (THF). To the resultant solution, 10 ml of solution containing 10 mmole of 1,3-diaminoadamantane obtained by the method of Example 65 in N,N-dimethylformamide (DMF) was added and then stirred for 3 hours at 40° C. As a result, the conversion of 1,3-diaminoadamantane was 99%, and 1,3-bis(acetylamino)adamantane (yield 95%) was formed.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06468487B1 |
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| Source dataset | uspto-grants-2002_10 |
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| ORD ID | ord-dda9b35d9b2e4a14a9ebecad2e5bca03 |
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| Source note | uspto-grants-2002_10 |
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