反应详情

温度

40 °C

In an atmosphere of nitrogen, 22 mmole of acetyl chloride and 24 mmole of triethylamine were dissolved in 2 ml of tetrahydrofurane (THF). To the resultant solution, 10 ml of solution containing 10 mmole of 1,3-diaminoadamantane obtained by the method of Example 65 in N,N-dimethylformamide (DMF) was added and then stirred for 3 hours at 40° C. As a result, the conversion of 1,3-diaminoadamantane was 99%, and 1,3-bis(acetylamino)adamantane (yield 95%) was formed.

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